Binding (Ki nM) | Antagonist (Kb nM) | |||||
---|---|---|---|---|---|---|
μ | δ | κ | μ | δ | κ | |
Naldemedine | 0.34 ± 0.03 | 0.43 ± 0.08 | 0.79 ± 0.08 | 0.50 ± 0.05 | 0.27 ± 0.03 | 0.32 ± 0.03 |
Naloxone | 0.43 ± 0.70 | 52.09 ± 4.13 | 2.63 ± 0.66 | 0.55 ± 0.06 | 24.74 ± 1.74 | 18.43 ± 9.73 |
Naloxegol | 0.49 ± 0.10 | 62.12 ± 26.63 | 40.78 ± 2.14 | 0.38 ± 0.08 | 6.26 ± 0.89 | 38.51 ± 10.92 |