TABLE 1

Selectivity of BNC375 against other Cys-loop family of ligand-gated ion channels

Cys-loop receptorPAM EC50 μMAntagonist IC50 μM
nAChR α1>10>10
nAChR α3β4>104.70
nAChR α4β2>10>10
nAChR α72.64>10
GABAA>10>10
5-HT3AND6.47