Pharmacodynamic parameter estimates of PF06821497 for tumor growth inhibition in DLBCL xenograft models after repeated administration
Precision of the estimates is expressed as S.E. in parentheses. Tumor growth rates (ktg) in vehicle control groups were estimated to be 2.16 (0.0247) and 2.26 (0.0242) × 10−3 h−1 in studies 1 and 2, respectively.
| Model | Kmax | KC50 | KE50 | τ |
|---|---|---|---|---|
| ng/ml | ratio | h | ||
| III | 2 | 1110 (121) | − | − |
| IV | 2 | 357 (51.9) | − | 87.0 (11.2) |
| V | 2 | − | 2.30 (0.363) | 85.1 (11.8) |
−, not applicable.