TABLE 3

Selectivity of ubrogepant for cloned CTR, AM1, AM2, AMY1, and AMY3 receptors in HEK293 cellsa

Target ReceptorSelectivity
Potency Difference Over CGRP Receptorb (IC50 = 0.08 nM)
AM1>10,000
AM2>10,000
Calcitonin (CTR)>10,000
AMY1105
AMY32737

  • IC50, half-maximal inhibitory concentration.

  • ↵a n = 3–19.

  • ↵b Calculated as (target receptor IC50 − CGRP receptor IC50)/CGRP receptor IC50.