TABLE 1

Analysis of blood gas parameters, electrolytes, and urinalysis parameters at 24 h after saline, O2-RBC, or CO-RBC treatment of glycerol-induced rhabdomyolysis model rats

Proteinuria and pH were evaluated using urine test paper. Scores 0, 1, 2, 3, 4, and 5 for proteinuria correspond to negative, false negative, 30, 100, 300, and 1000 mg/dl of protein, respectively. Scores 5–9 directly correspond to urinary pH 5–9. All unianalyses were performed under blind conditions. Values are shown as the mean ± S.E. (n = 3–5).

pHBase Excess (mmol/l)Lactate (mmol/l)K+ (mEq/l)Na+ (mEq/l)Hemoglobin (g/dl)Urinary ProteinUrinary pH
Control7.41 ± 0.021.8 ± 0.70.9 ± 0.14.46 ± 0.02134 ± 1.013.8 ± 0.91.7 ± 1.27.66 ± 0.58
Saline7.31 ± 0.02*−2.1 ± 1.1**2.8 ± 1.2**7.12 ± 0.28**117 ± 3.0*11.4 ± 1.9*3.7 ± 0.8*5.66 ± 0.58**
O2-RBC7.33 ± 0.01*−2.7 ± 1.9**2.7 ± 1.1**6.78 ± 0.22**118 ± 2.4*15.6 ± 0.9##4.0 ± 1.0*6.33 ± 0.58**
CO-RBC7.38 ± 0.04#−1.3 ± 1.7*#1.2 ± 1.2##5.52 ± 0.18*#124 ± 2.013.6 ± 1.1#1.3 ± 0.8#7.00 ± 1.00*#
  • * P < 0.05; **P < 0.01 vs. control. #P < 0.05; ##P < 0.01 vs. saline.