TABLE 2

In vitro displacement times (t1/2) and dissociation rate constants (kd) of JNJ-42226314 with MAGL from human, mouse, and rat brain membranes

Values are expressed as the average ± S.D. (N = 3 experiments).

MAGLt1/2 (min)kd (min−1)
Human11.4 ± 2.20.062 ± 0.013
Mouse27.6 ± 5.50.026 ± 0.005
Rat27.2 ± 2.10.026 ± 0.002