TABLE 6

Isobolographic analysis showing theoretical (EF50 add) and experimentally determined (EF50 mix) values of AP and TG combinations against 6-Hz-induced seizures

AED CombinationFixed RatioAP + TG = ED50 mix (mg/kg)nmixEF50 add = AP + TG (mg/kg)nadd
AP + TG1:32.4220.0422.464 (1.705–4.058)321.199 (0.75–1.74)1.050.14932
AP + TG1:10.7970.0380.835 (0.559–1.247)322.199 (1.40–3.10)2.10.09932
AP + TG3:10.3770.0590.436 (0.24–0.791)323.200 (2.05–4.45)3.150.05032
  • nadd, total animal numbers used to calculate the theoretical line of additivity; nmix, total animal numbers in each mixture of drug combinations.