TABLE 8

Isobolographic analysis showing theoretical (EFtwofold add) and experimentally determined (EFtwofold mix) values of GX and MDZ combinations on tonic potentiation in DGGCs

AED CombinationFixed RatioGX + MDZ = EFtwofold mix (nM)nmixEFtwofold add = GX + MDZ (nM)nadd
GX + MDZ1:343.017.060.0 ± 24.0687.3 ± 14.962.524.86
GX + MDZ1:184.611.295.8 ± 31.06141.5 ± 21.312516.56
GX + MDZ3:179.43.582.9 ± 21.76195.8 ± 27.6187.58.36
  • nadd, total cell numbers used to calculate the theoretical line of additivity; nmix, total cell numbers in each mixture of drug combinations.