TABLE 5

Isobolographic analysis showing theoretical (EFtwofold add) and experimentally determined (EFtwofold mix) values of AP and TG combinations on tonic current potentiation in DGGCs

AED CombinationFixed RatioAP + TG = EFtwofold mix (nM)nmixEFtwofold add = AP + TG (nM)nadd
AP + TG1:327.663.290.8 ± 28.26237 ± 35.3721656
AP + TG1:160.846.5107.3 ± 20.66254 ± 27.51441106
AP + TG3:136.19.245.3 ± 15.66271 ± 19.8216556
  • nadd, total cell numbers used to calculate the theoretical line of additivity; nmix, total cell numbers in each mixture of drug combinations.