TABLE 2

Isobolographic analysis showing theoretical (EFtwofold add) and experimentally determined (EFtwofold mix) values of GX and TG combinations on tonic current potentiation in DGGCs

AED CombinationFixed RatioGX + TG = EFtwofold mix (nM)nmixEFtwofold add = GX + TG (nM)nadd
GX + TG1:322.659.682.2 ± 24.27227.5 ± 40.862.51656
GX + TG1:144.138.883.0 ± 18.57235 ± 38.51251106
GX + TG3:1134.339.4173.6 ± 20.58242.5 ± 36.3187.5556
  • nadd, total cell numbers used to calculate the theoretical line of additivity; nmix, total cell numbers in each mixture of drug combinations.