Compound | Mean (nM) ± S.E.M. | ||||||||
---|---|---|---|---|---|---|---|---|---|
PTP4A1 | PTP4A2 | PTP4A3 | PTP4A3 C49S | PTP4A3 K144I | PTP4A3 A106V | PTP4A3 A111S | CDC25B | DUSP3 | |
JMS-053 | 29.1 ± 2.7 | 48.0 ± 14.5 | 34.7 ± 2.5a | 156.5 ± 20.1b | 42.7 ± 8.0 | 26.3 ± 2.5 | 104.4 ± 7.7b,c | 92.6 ± 10.2 | 207.6 ± 46.3 |
EJR-866-81 | 49.0 ± 5.0 | 112.9 ±10.0b | 36.1 ± 1.4 | 390.0 ± 72.5b | 59.1 ± 5.9 | 54.5 ± 2.4 | 61.0 ± 2.8b,c | 65.5 ± 16.6 | 240.8 ± 30.9 |
EJR-866-75 | 43.2 ± 8.5 | 73.9 ± 10.0 | 98.2 ± 2.5d | 229.7 ±54.6b | 68.5 ± 1.0 | 57.5 ± 18.6 | 172.0 ± 46.0b,c,d | 122.6 ± 22.6 | 521.0 ± 128.4 |
NRT-870-59e | 133.2 ± 31.7a | 264.4 ± 37.4a,b | 86.0 ± 12.6a | 332.2 ± 52.5b | 180.2 ± 64.5e | 57.7 ± 18.6 | >1000c | >1000 | 411.8 ± 75.3 |
JMS-038 | >1000 | >1000 | >1000 | ND | >1000 | ND | ND | ND | >1000 |