TABLE 3

Statistical summary of treatment comparisons

IN Administration (Test)Comparison (i.m. as Reference)Ratio (Test/Reference) of Adjusted Meansa90% CI for Ratio
Cmax/dose (ng/ml/mg)
 3 mg IN (trt A)A vs. D65.849.6–87.2
 3 mg/0.25% DDM IN (trt B)B vs. D135100–180
 1.5 mg IN (trt C)C vs. D63.446.6–86.4
AUC0–inf/dose (ng·h/ml/mg)
 3 mg IN (trt A)A vs. D63.153.1–74.9
 3 mg/0.25% DDM IN (trt B)B vs. D69.558.1–83.2
 1.5 mg IN (trt C)C vs. D55.445.8–67.1
  • AUC0–inf/dose, AUC per milligram of naloxone administered; Cmax/dose, Cmax per milligram of naloxone administered; trt, treatment.

  • a Geometric least-squares mean ratio between treatments, expressed as a percentage of reference (i.m., treatment D).