TABLE 1

Silymarin flavonolignan pharmacokinetics

The percent extrapolation from AUC_{0–120 min} to AUC_{120 min–inf} for the silymarin flavonolignans ranged from 0.23% to 18%. Data represent mean and S.E.M. of four rats.

	AUC_0–inf	t_1/2	Cl	V_ss
	nmol × min/ml	min	ml/min	l
Silybin A
Control	18.1 ± 1.9	14.9 ± 2.4	41.8 ± 5.3	0.51 ± 0.04
NASH	27.7 ± 2.8^*	29.1 ± 5.8	17.4 ± 2.1^*	0.27 ± 0.03^*
Silybin B
Control	33.6 ± 2.3	20.8 ± 2.2	39.4 ± 3.2	0.61 ± 0.06
NASH	50.2 ± 5.7^*	34.6 ± 4.4^*	17.2 ± 1.9^*	0.28 ± 0.04^*
Silychristin
Control	105.6 ± 3.7	48.1 ± 11.8	13.2 ± 0.7	0.32 ± 0.01
NASH	112.4 ± 4.2	61.2 ± 6.6	7.9 ± 0.4^*	0.19 ± 0.01^*
Silydianin
Control	11.2 ± 0.6	40.2 ± 4.2	30.5 ± 1.6	0.82 ± 0.05
NASH	14.8 ± 1.8	54.2 ± 8.5	15.2 ± 1.9^*	0.41 ± 0.06^*
Isosilybin A
Control	9.6 ± 0.8	17.4 ± 2.9	46.5 ± 4.5	0.69 ± 0.04
NASH	19.4 ± 1.9^*	30.8 ± 4.4^*	14.6 ± 1.3^*	0.28 ± 0.04^*
Isosilybin B
Control	9.9 ± 0.9	21.5 ± 2.0	21.6 ± 2.3	0.38 ± 0.03
NASH	20.1 ± 1.8^*	38.9 ± 8.6	6.8 ± 0.5^*	0.13 ± 0.02^*

AUC_0–inf, area under the plasma concentration-time curve from time zero to infinite time; t_1/2, terminal half-life.
↵* P value ≤0.05 vs. control (unpaired t test).