Plasma protein binding of RAM2061 and RAM2093 in mouse plasma (n = 3, mean ± S.D.)
| Parameters | Mean ± S.D. | |
|---|---|---|
| RAM2061 | RAM2093 | |
| % Remaining at 5 h (stability) | 109.5 ± 8.9 | 106.3 ± 8.1 |
| % Device recovery | 116.3 ± 5.8 | 112.3 ± 6.3 |
| % Plasma protein bound (at 1 μg/ml spiked sample) | 94.8 ± 0.4 | 96.2 ± 0.4 |
| % Plasma protein bound (at 10 μg/ml spiked sample) | 93.6 ± 1.8 | 93.9 ± 0.9 |
| % Plasma protein bound (2 h postinfusion (0.3 mg/kg i.v.)) | 94.8 ± 0.2 | 92.8 ± 1.3 |
| % Plasma protein bound (8 h postinfusion (0.3 mg/kg i.v.)) | 96.3 ± 0.3 | 92.5 ± 1.8 |