TABLE 6

CRV431 concentrations in blood and liver Means ± S.D.

SpeciesStudy Treatmentsmg/kg per dayDay of DosingHours Post-DosenBlood µg/mlLiver µg/gLiver:Blood [CRV431] Ratio
MouseNASH501893101.4 ± 1.511.6 ± 9.011.9 ± 8.5
MouseCCl45042491.2 ± 0.514.5 ± 2.915.4 ± 10.4
Rat3071261.8 ± 0.311.7 ± 1.96.6 ± 1.1
Rat3072461.3 ± 0.26.0 ± 1.44.8 ± 1.1
Rat25071263.2 ± 0.723.4 ± 3.47.6 ± 1.8
Rat25072462.9 ± 0.615.2 ± 4.05.3 ± 0.6