TABLE 3

Inhibition of cyclophilin

Cyclophilin IsoformCsA IC50 (nM)CRV431 IC50 (nM)IC50 Fold Difference
PPIA (Cyp A)25.62.510.2
PPIB (Cyp B)11.53.13.7
PPIF (Cyp D)10.12.83.6
PPIG (Cyp G)27.77.33.8
  • PPIB, peptidyl prolyl isomerase B; PPIF, peptidyl prolyl isomerase F; PPIG, peptidyl prolyl isomerase G.