TABLE 3

Spearman correlation coefficients among the estimated PBPK parameters, demographic and physiologic data, and uremic solute concentrations in 12 healthy subjects

IVIVE adjustment (adjustment factor)	Height	Weight	BMI	Age	eGFR	SCr	BUN	TNF-α
	cm	kg	kg/m²	years	l/h	mg/dl	mg/dl	pg/ml
Meta-uptake transporter
ρ^{^a}	0.371	0.147	−0.259	−0.372	0.007	0.351	−0.608	−0.161
P value	0.235	0.648	0.417	0.234	0.983	0.263	0.036^{^b}	0.618
CYP3A4 clearance
ρ	−0.529	−0.378	0.154	0.319	−0.571	0.092	−0.504	−0.399
P value	0.077	0.225	0.633	0.312	0.053	0.775	0.095	0.199
Total passive diffusion between ES and LC
ρ	0.476	0.308	−0.175	−0.204	−0.175	0.414	−0.196	0.112
P value	0.117	0.330	0.589	0.526	0.586	0.181	0.542	0.729

BMI, body mass index; eGFR, estimated glomerular filtration rate; SCr, serum creatinine; TNF-α, tumor necrosis factor.-α
↵^a Spearman correlation coefficient.
↵^b P < 0.05 indicates a statistically significant correlation.