TABLE 3

Spearman correlation coefficients among the estimated PBPK parameters, demographic and physiologic data, and uremic solute concentrations in 12 healthy subjects

IVIVE adjustment (adjustment factor)HeightWeightBMIAgeeGFRSCrBUNTNF-α
cmkgkg/m2yearsl/hmg/dlmg/dlpg/ml
Meta-uptake transporter
 ρa0.3710.147−0.259−0.3720.0070.351−0.608−0.161
 P value0.2350.6480.4170.2340.9830.2630.036b0.618
CYP3A4 clearance
 ρ−0.529−0.3780.1540.319−0.5710.092−0.504−0.399
 P value0.0770.2250.6330.3120.0530.7750.0950.199
Total passive diffusion between ES and LC
 ρ0.4760.308−0.175−0.204−0.1750.414−0.1960.112
 P value0.1170.3300.5890.5260.5860.1810.5420.729
  • BMI, body mass index; eGFR, estimated glomerular filtration rate; SCr, serum creatinine; TNF-α, tumor necrosis factor.-α

  • a Spearman correlation coefficient.

  • b P < 0.05 indicates a statistically significant correlation.