Spearman correlation coefficients among the estimated PBPK parameters, demographic and physiologic data, and uremic solute concentrations in 12 healthy subjects
IVIVE adjustment (adjustment factor) | Height | Weight | BMI | Age | eGFR | SCr | BUN | TNF-α |
---|---|---|---|---|---|---|---|---|
cm | kg | kg/m2 | years | l/h | mg/dl | mg/dl | pg/ml | |
Meta-uptake transporter | ||||||||
ρa | 0.371 | 0.147 | −0.259 | −0.372 | 0.007 | 0.351 | −0.608 | −0.161 |
P value | 0.235 | 0.648 | 0.417 | 0.234 | 0.983 | 0.263 | 0.036b | 0.618 |
CYP3A4 clearance | ||||||||
ρ | −0.529 | −0.378 | 0.154 | 0.319 | −0.571 | 0.092 | −0.504 | −0.399 |
P value | 0.077 | 0.225 | 0.633 | 0.312 | 0.053 | 0.775 | 0.095 | 0.199 |
Total passive diffusion between ES and LC | ||||||||
ρ | 0.476 | 0.308 | −0.175 | −0.204 | −0.175 | 0.414 | −0.196 | 0.112 |
P value | 0.117 | 0.330 | 0.589 | 0.526 | 0.586 | 0.181 | 0.542 | 0.729 |