Spearman correlation coefficients among the estimated PBPK parameters, demographic and physiologic data, and uremic solute concentrations in 12 healthy subjects

IVIVE adjustment (adjustment factor)HeightWeightBMIAgeeGFRSCrBUNTNF-α
Meta-uptake transporter
 P value0.2350.6480.4170.2340.9830.2630.036b0.618
CYP3A4 clearance
 P value0.0770.2250.6330.3120.0530.7750.0950.199
Total passive diffusion between ES and LC
 P value0.1170.3300.5890.5260.5860.1810.5420.729
  • BMI, body mass index; eGFR, estimated glomerular filtration rate; SCr, serum creatinine; TNF-α, tumor necrosis factor.-α

  • a Spearman correlation coefficient.

  • b P < 0.05 indicates a statistically significant correlation.