Parameter estimates through the nested optimization and normalized residuals in the iPBPK-R modeling of the ERMBT study in 12 healthy subjects
| Estimated parameter | Mean ± S.D. | Median (Range) |
|---|---|---|
| IVIVE adjustment (adjustment factor) | ||
| Meta-uptake transporter | 0.84 ± 0.26 | 0.98 (0.23, 1.00) |
| P-gp | 1.00 ± 0.00 | 1.00 (1.00,1.00) |
| MRP2 | 1.00 ± 0.00 | 1.00 (1.00, 1.00) |
| CYP3A4 clearance | 0.14 ± 0.06 | 0.12 (0.07, 0.24) |
| Hepatocyte volume | 0.78 ± 0.19 | 0.73 (0.50, 1.01) |
| Partition coefficient in the combined other organs | 18.77 ± 0.03 | 18.78 (18.72, 18.84) |
| Blood flow in the combined other organs | 0.80 ± 0.27 | 0.87 (0.45, 1.22) |
| Exponential decay parameter in the combined other organs | 3.99 ± 0.01 | 3.99 (3.97, 4.03) |
| Total passive diffusion between ES and LC | 0.60 ± 0.21 | 0.67 (0.13, 0.87) |
| Model fit: normalized residual | 10−4 ± 10−4 | 0.0001 (0, 4 × 10−4) |