TABLE 2

Parameter estimates through the nested optimization and normalized residuals in the iPBPK-R modeling of the ERMBT study in 12 healthy subjects

Estimated parameterMean ± S.D.Median (Range)
IVIVE adjustment (adjustment factor)
 Meta-uptake transporter0.84 ± 0.260.98 (0.23, 1.00)
 P-gp1.00 ± 0.001.00 (1.00,1.00)
 MRP21.00 ± 0.001.00 (1.00, 1.00)
 CYP3A4 clearance0.14 ± 0.060.12 (0.07, 0.24)
 Hepatocyte volume0.78 ± 0.190.73 (0.50, 1.01)
 Partition coefficient in the combined other organs18.77 ± 0.0318.78 (18.72, 18.84)
 Blood flow in the combined other organs0.80 ± 0.270.87 (0.45, 1.22)
 Exponential decay parameter in the combined other organs3.99 ± 0.013.99 (3.97, 4.03)
 Total passive diffusion between ES and LC0.60 ± 0.210.67 (0.13, 0.87)
Model fit: normalized residual10−4 ± 10−40.0001 (0, 4 × 10−4)