Parameter estimates through the nested optimization and normalized residuals in the iPBPK-R modeling of the ERMBT study in 12 healthy subjects
Estimated parameter | Mean ± S.D. | Median (Range) |
---|---|---|
IVIVE adjustment (adjustment factor) | ||
Meta-uptake transporter | 0.84 ± 0.26 | 0.98 (0.23, 1.00) |
P-gp | 1.00 ± 0.00 | 1.00 (1.00,1.00) |
MRP2 | 1.00 ± 0.00 | 1.00 (1.00, 1.00) |
CYP3A4 clearance | 0.14 ± 0.06 | 0.12 (0.07, 0.24) |
Hepatocyte volume | 0.78 ± 0.19 | 0.73 (0.50, 1.01) |
Partition coefficient in the combined other organs | 18.77 ± 0.03 | 18.78 (18.72, 18.84) |
Blood flow in the combined other organs | 0.80 ± 0.27 | 0.87 (0.45, 1.22) |
Exponential decay parameter in the combined other organs | 3.99 ± 0.01 | 3.99 (3.97, 4.03) |
Total passive diffusion between ES and LC | 0.60 ± 0.21 | 0.67 (0.13, 0.87) |
Model fit: normalized residual | 10−4 ± 10−4 | 0.0001 (0, 4 × 10−4) |