[125I]RTI-55 binding in synaptosomes
Data represent mean ± S.E.M. for each genotype and treatment group from four independent experiments, n = 4 mice per genotype per treatment group.
| Treatment | Genotype | Bmax S.E.M. | Kd ± S.E.M. |
|---|---|---|---|
| pmol/mg protein | nM | ||
| Saline | Taar1 WT | 10.3 ± 0.8 | 3.7 ± 0.2 |
| Taar1 KO | 11.7 ± 1.3 | 4.3 ± 0.4 | |
| MA | Taar1 WT | 8.5 ± 0.4* | 3.6 ± 0.4 |
| Taar1 KO | 7.6 ± 1.0* | 3.8 ± 0.7 |
* P < 0.01 compared with saline treatment (main effect).