TABLE 1

Receptor affinities.

Panel screens of up to 105 radioligand-binding assays and 34 enzyme assays were performed, and the affinity of SEP-856 was determined for receptors at which >50% inhibition was seen at 10 μM. Details of radioligands, incubation conditions , and the targets in the screening panels are listed in the Supplemental Material. Data are shown as mean ± S.E.M. (n ≥ 3, n = 1 for 5-HT_2B).