TABLE 2

Comparison of mechanisms controlling pharmacokinetic processes

Drug ClassAbsorptionDistributionMetabolism/Elimination
Small moleculesGut wall permeabilityPlasma protein bindingRenal filtration
Active transportDiffusionActive transport
Drug metabolismActive transportDrug metabolism
BiologicsRenal filtration
Lymph flowDiffusionIntracellular catabolism
FcRn bindingBulk fluid flowTarget-mediated clearance
NanoparticlesN/ABulk fluid flowReticuloendothelial system
Target-mediated clearance
  • FcRn, neonatal Fc receptor; N/A, not applicable.