TABLE 3

IC50 concentration and combination index of the developed formulation in MDA MB 231 and B16F10 cells

Nanoparticle/DrugMDA MB 231B16F10
Tpt4.51 ± 0.75 μMC.I. = 0.936.4 ± 0.98 μMC.I. = 0.85
Cur+Tpt (Tpt)3 ± 0.10 μM2.8 ± 0.2 μM
Tpt_NC0.90 ± 0.03 μM1.1 ± 0.08 μM
Cur_Tpt_NC (Tpt)0.35 ± 0.09 μM0.43 ± 0.12 μM
Tpt_NC.MB5.75 ± 0.42 μM1.89 ± 0.23 μM
Tpt_NC.MB +US20.07 ± 0.013 μM0.12 ± 0.01 μM
Cur_Tpt_NC.MB (Tpt)0.91 ± 0.23 μM0.9 ± 0.23 μM
Cur_Tpt_NC.MB+US2 (Tpt)0.04 ± 0.011 μM0.063 ± 0.02 μM
Cur21.25 ± 4.2 μM16.67 ± 3.4 μM
Cur+Tpt (Cur)4 ± 0.40 μM6.56 ± 1.2 μM
Cur_NC0.48 ± 0.04 μM1.77 ± 0.45 μM
Cur_Tpt_NC (Cur)0.28 ± 0.01 μM0.3 ± 0.03 μM
Cur_NC.MB1.34 ± 0.28 μM1.77 ± 0.45 μM
Cur_NC.MB+US20.22 ± 0.023 μM0.33 ± 0.02 μM
Cur_Tpt_NC.MB (Cur)0.85 ± 0.1 μM0.93 ± 0.1 μM
Cur_Tpt_NC.MB+US2 (Cur)0.08 ± 0.010 μM0.11 ± 0.02 μM
  • C.I., combination index.