TABLE 5

Bone length [millimeters [95% confidence interval] (% change from control)] determined by X-ray after 5 wk of daily bolus injection or continuous infusion of CNP-38 or vehicle control in FVB mice

	Subcutaneous Bolus Injection		Subcutaneous Continuous Infusion
Measurement	Vehicle Control	CNP-38 203 µg/kg Per Day	Vehicle Control	CNP-38 203 µg/kg Per Day
Femur length^{^a}	14.2 [13.7; 14.8]	15.0 [14.5; 15.6] (5.5%)^*	13.6 [13.0; 14.1]	14.6 [14.1; 15.2] (7.1%)^*
Tibia length^{^b}	17.9 [17.7; 18.1]	18.7 [18.5; 18.9] (4.0%)^*	17.6 [17.4; 17.8]	19.8 [19.6; 20.0] (12.2%)*^,#
Spine length^{^c}	53.8 [52.4; 55.2]	59.8 [58.5; 61.2] (11.3%)^*	53.6 [52.2; 55.0]	67.0 [65.6; 68.4] (25.0%)*^,#

↵^a Right femur.
↵^b Right tibia.
↵^c Lateral view.
↵^* Different from vehicle control; ^#different from growth under subcutaneous bolus injection (one-factor ANOVA model on logarithmic transformed data); P < 0.05.