Mean pharmacokinetic parameters of CNP (after first dose) released from TransCon CNP following administration of TransCon CNP compared with the daily CNP-39 molecule in monkeys

GroupDose (µg CNP/kg)Tmaxa (h)Cmax (pmol/l)AUC(0-t) (h × pmol/l)T1/2 (h)
Daily CNP-39 molecule20/day0.25385025600.35
TransCon CNP40/wk4816.5174892.6
TransCon CNP100/wk2439.4418686.7
  • AUC, area under the curve; T1/2, half-life; Tmax, time to maximum plasma concentration.

  • a Median Tmax is presented.