Mean pharmacokinetic parameters of CNP (after first dose) released from TransCon CNP following administration of TransCon CNP compared with the daily CNP-39 molecule in monkeys
| Group | Dose (µg CNP/kg) | Tmaxa (h) | Cmax (pmol/l) | AUC(0-t) (h × pmol/l) | T1/2 (h) |
|---|---|---|---|---|---|
| Daily CNP-39 molecule | 20/day | 0.25 | 3850 | 2560 | 0.35 |
| TransCon CNP | 40/wk | 48 | 16.5 | 1748 | 92.6 |
| TransCon CNP | 100/wk | 24 | 39.4 | 4186 | 86.7 |
AUC, area under the curve; T1/2, half-life; Tmax, time to maximum plasma concentration.
↵a Median Tmax is presented.