Histomorphometry data of the proximal tibial growth plate following weekly administration of TransCon CNP compared with the daily CNP-39 molecule for 26 wk to monkeys (% change from vehicle control)
| Treatment | |||
|---|---|---|---|
| TransCon CNP 40 µg CNP/kg Per Week | TransCon CNP 100 µg CNP/kg Per Week | Daily CNP-39 Molecule 20 µg/kg Per Day | |
| No. animals per group | 4 | 4 | 4 |
| Bone, tibia (no. measured) | 4 | 4 | 4 |
| Proliferative zone width | −2 | 37a | 16a |
| Hypertrophic zone width | 7 | 38a | 39a |
| Epiphyseal plate thickness | −4 | 16a | 7 |
↵a Significantly different from control group; P ≤ 0.05, based on statistical analysis of group means.