Histomorphometry data of the proximal tibial growth plate following weekly administration of TransCon CNP compared with the daily CNP-39 molecule for 26 wk to monkeys (% change from vehicle control)

TransCon CNP 40 µg CNP/kg Per WeekTransCon CNP 100 µg CNP/kg Per WeekDaily CNP-39 Molecule 20 µg/kg Per Day
No. animals per group444
Bone, tibia (no. measured)444
Proliferative zone width−237a16a
Hypertrophic zone width738a39a
Epiphyseal plate thickness−416a7
  • a Significantly different from control group; P ≤ 0.05, based on statistical analysis of group means.