TABLE 2

Comparison of tissue KP values for DEX determined by different methods Values are listed as the mean ± S.D.

Tissue (Sex)In Vivo KPfu,t(invitro)In Vitro KPMethod 1Method 2Method 3
Liver (male)5.5 ± 0.3a0.050 ± 0.0013.6 ± 0.5c1.30.70.6
4.8 ± 0.5b0.068 ± 0.0012.6 ± 0.4d
Liver (female)0.059 ± 0.0043.0 ± 0.5c
0.070 ± 0.0032.5 ± 0.4d
Lung (male)0.53 ± 0.02a0.115 ± 0.0061.5 ± 0.3d1.40.80.6
0.43 ± 0.05b
Muscle (male)0.50 ± 0.0a0.236 ± 0.030.74 ± 0.1d0.90.60.34
0.49 ± 0.04b
  • a Subcutaneous injection.

  • b Subcutaneous infusion.

  • c Low DEX concentration (1 μg/ml).

  • d High DEX concentration (10 μg/ml).