TABLE 1

Comparison of tissue KP values for MPL determined by different methods Values are listed as the mean ± S.D.

Tissue (Sex)In Vivo KPfu,t (in vitro)In Vitro KPMethod 1Method 2Method 3
Liver (male)13.4 ± 0.9a0.162 ± 0.012.5 ± 0.21.20.90.8
13.3 ± 1.4b
Liver (female)11.4 ± 1.4a0.066 ± 0.0036.1 ± 0.4
Lung (male)2.3 ± 0.0b0.192 ± 0.012.1 ± 0.11.31.00.9
Muscle (male)1.8 ± 0.4b0.298 ± 0.051.4 ± 0.20.90.80.6
  • a Intramuscular injection.

  • b Subcutaneous infusion.