TABLE 3

PD parameter estimates for plasma CST suppression by MPL

Parameter	Definition	Estimate (% CV)
Circadian Rhythm Parameters for CST
T (h)	Biorhythmic period	24^{^a}^,^{^b}^,^{^c}
a₀	Fourier coefficient	115.7^{^a}^,^{^b}/254.4^{^b}
a₁		−120.9^{^a}^,^{^b}/−168.7^{^b}
a₂		38.8^{^a}^,^{^b}/56.9^{^b}
b₁		−41.1^{^a}^,^{^b}/−95.6^{^b}
b₂		1.6^{^a}^,^{^b}/29.1^{^b}
Pharmacodynamic Parameters
k_deg,CST (h⁻¹)	Loss rate constant for CST	1.38 (12.6)^{^a}^,^{^b}^,^{^c}
τ (h)	Time to CST_stress	0.34 (12.8)^{^a}^,^{^b}^,^{^c}
CST_stress (ng/ml)	Maximal CST due to stress	535 (18.0)^{^a}/1292 (13.3)^{^b}/1397 (12.9)^{^c}
IC_50,CST (ng/ml)	Half-maximal inhibition concentration	3.4 (47.6)^{^a}/41.6 (48.0)^{^b}/12.9 (45.6)^{^c}