TABLE 2

PK parameter values for the mPBPK model of MPL

Parameter	Definition	Estimate (% CV)
F	Bioavailability	0.214^{^a}
Fr	Fraction absorbed by k_a1	0.725^{^a}
k_a1 (h⁻¹)	Absorption rate constant	0.8 (8.8)^{^b}/4.1 (24.8)^{^c}
k_a2 (h⁻¹)	Absorption rate constant	0.17 (17.3)
CL_EH (ml/h)	Extrahepatic clearance	347 (4.2)
CL_u,int,male (ml/h)	Hepatic unbound intrinsic clearance (male)	2987 (12.7)
K_{P, hep}	Partition coefficient—liver	12.6 (7.6)
K_{P, PPT (muscle)}	Partition coefficient—poorly perfused tissue	1.4^{^d}
K_{P, RPT (lung)}	Partition coefficient—richly perfused tissue	2.1^{^d}
f_u,p	MPL fraction unbound in plasma	0.4^{^d}