TABLE 3

Model parameters for glucocorticoid-induced leucine zipper (GILZ) mRNA dynamics

ParameterDefinitionEstimate (% CV)
kd,GILZm (h−1)Degradation rate constant for GILZ7.5 (21.8)a; 1.9 (27.5) b
SmaxMaximal stimulatory capacity by DRN7.5a,b,c
SC50,GILZm (fmol/mg)DRN producing half-maximal stimulation558 (5.5)a; 672 (19.2)b
Ki (fmol/mg)ERN producing half-maximal inhibition of SC50 of DRN62.1 (68.6)a,b
GILZm(0) (molecules/ng of RNA)GILZ initial concentration in liver1893 (M); 2051 (E); 2538 (PE)
GILZm(0) (molecules/ng RNA)GILZ initial concentration in uterus3245 (E); 2400 (PE)
  • a Liver.

  • b Uterus.

  • c Hazra et al. (2008).