TABLE 1

Model parameters for glucocorticoid receptor (GR) dynamics

Parameter	Definition	Estimate (CV%)
a_0,GRm,liver	Fourier coefficient for liver GR mRNA^{^a}	14.3
a_1,GRm,liver		−1.53
a_2,GRm,liver		0.554
b_1,GRm,liver		−3.04
b_2,GRm,liver		1.18
k_d,GRm (h⁻¹)	Degradation rate constant for GR mRNA	0.14 (17.0)
IC_50,GRm (fmol/mg)	Half-maximal inhibition of GR mRNA production	15.2^{^a}
τ_GRm (h)	Transduction delay for mRNA rebound	15.6^{^a}
IC_50,TC2 (fmol/mg)	Half-maximal inhibition of GR mRNA removal	60.5^{^a}
k_d,GR (h⁻¹)	Degradation rate constant for receptor	0.05^{^a}
k_on,MPL (nM⁻¹·h⁻¹)	Association rate constant for methylprednisolone (MPL)	0.016^{^a}
k_on,CST (nM⁻¹·h⁻¹)	Association rate constant for corticosterone (CST)	0.001 (fixed)
f_up,mpl	Unbound fraction of MPL in plasma	0.4^{^b}
f_u,liv,mpl	Unbound fraction of MPL in liver	0.032 (calculated)
f_u,cst	Unbound fraction of CST in plasma	0.017^{^a}
k_re (h⁻¹)	DR_N nuclear loss rate constant	1.31^{^a}
R_f	Fraction recycled	0.93^{^a}
k_T (h⁻¹)	Translocation rate constant	58.3^{^a}
GR(0) (fmol/mg protein)	Free cytosolic receptor initial concentration	476.0 (liver)^{^a} 320.0 (uterus)^{^c}