TABLE 1

Model parameters for glucocorticoid receptor (GR) dynamics

ParameterDefinitionEstimate (CV%)
a0,GRm,liverFourier coefficient for liver GR mRNAa14.3
a1,GRm,liver−1.53
a2,GRm,liver0.554
b1,GRm,liver−3.04
b2,GRm,liver1.18
kd,GRm (h−1)Degradation rate constant for GR mRNA0.14 (17.0)
IC50,GRm (fmol/mg)Half-maximal inhibition of GR mRNA production15.2a
τGRm (h)Transduction delay for mRNA rebound15.6a
IC50,TC2 (fmol/mg)Half-maximal inhibition of GR mRNA removal60.5a
kd,GR (h−1)Degradation rate constant for receptor0.05a
kon,MPL (nM−1·h−1)Association rate constant for methylprednisolone (MPL)0.016a
kon,CST (nM−1·h−1)Association rate constant for corticosterone (CST)0.001 (fixed)
fup,mplUnbound fraction of MPL in plasma0.4b
fu,liv,mplUnbound fraction of MPL in liver0.032 (calculated)
fu,cstUnbound fraction of CST in plasma0.017a
kre (h−1)DRN nuclear loss rate constant1.31a
RfFraction recycled0.93a
kT (h−1)Translocation rate constant58.3a
GR(0) (fmol/mg protein)Free cytosolic receptor initial concentration476.0 (liver)a 320.0 (uterus)c
  • a Fixed from Hazra et al. (2007).

  • b Fixed from Ayyar et al. (2019).

  • c Fixed from Izawa et al. (1984).