TABLE 1

PK parameters using NCA for plasma MPL in the study cohorts after intramuscular administration

Experimental Group (n)λz (h−1)T1/2_λz (h)Cmax (ng/ml)AUC0-∞ (h × ng/ml)bCL/F (ml/h per kilogram)
Cohort 1: estrus female (30)0.242.95348 ± 48810,489 ± 10544767 ± 479
Cohort 2: proestrus female (39)0.272.63859 ± 7779142 ± 6465469 ± 386
Cohort 3: noncycler female (20)0.203.43796 ± 1888735 ± 6015723 ± 394
Cohort 4: male 7 wk (31)0.252.71470 ± 1092808 ± 16717,806 ± 1059
Cohort 5: male 11 wk (23)0.262.61054 ± 942885 ± 31217,334 ± 1875
All females0.242.94204 ± 3239751 ± 4825128 ± 252
All males0.282.51174 ± 1942901 ± 18517,232 ± 1099
  • CL/F, clearance; T1/2, half-life.

  • a Values represent mean ± S.E.

  • b AUC calculated using Bailer’s method for sparse (destructive) sampling.