TABLE 1

Probes and custom conjugates used to optimize and perform PK studies

ProbeMolecular MassDescriptionExcitation/EmissionApplications
kDanm
FRS6801.6Folate-based NIR fluorescent imaging probe670/690Oncology and inflammation
AS68070NIR fluorescent-labeled PEG-polylysine copolymer used as a vascular imaging probe670/690Vascularity and vascular leak changes in oncology and inflammation
AS75070NIR fluorescent-labeled PEG-polylysine copolymer used as a vascular imaging probe750/770Vascularity and vascular leak changes in oncology and inflammation
IS7501.28NIR fluorescent-labeled small molecule αVβ3 integrin antagonist755/775Oncology, atherosclerosis, angiogenesis
GFR680∼6.0NIR fluorescent-labeled inulin670/690Measuring GFR by blood PK
IgG1-VT680XL150Normal mouse IgG1 labeled with VivoTag 680XL665/688Control
  • PEG, polyethylene glycol.