TABLE 4

Efficacy of 5 weeks of ranolazine or best standard therapy (BST) on chemotherapy-induced diastolic dysfunction

ArmEvent at T1Event Outcome at T5Postrandomization EventsTreatment Failures
Ranolazine (n = 12)Impaired relaxation (n = 5)NormalizedNoneNone
Impaired relaxation + cTnI > ULNNormalized/normalizedNone
cTnI > ULNNormalizedNone
BNP > ULN (n = 4)Normalized (n = 3), Improved (n = 1)None
BNP > ULN + cTnI > ULNImproved-normalizedNone
BST (n = 12)Impaired relaxation (n = 2)NormalizedNone3
Impaired relaxationaNormalizedBNP > ULNa
Impaired relaxationbFailureNone
Impaired relaxationcFailureNone
BNP > ULN (n = 7)Normalized (n = 4), Improved (n = 3)None
  • BNP, B-type natriuretic peptide; cTnI, cardiac troponin isoform I; T1, 1 week after chemotherapy; T5, 5 weeks after randomization; ULN, upper limit of normal.

  • a Patient treated by ramipril (2.5 mg/day).

  • b Patient treated by bisoprolol (1.25 mg/day).

  • c Patient treated by bisoprolol + ramipril (2.5 mg/day + 5 mg/day).