Mean ± S.D. urine CPX and CPX-G pharmacokinetic parameters in male beagle dogs following single doses of intravenous CPX-POM, SC CPX-POM, and oral CPX-O
| Treatmenta | |||
|---|---|---|---|
| Parameter | CPX-POM Intravenous | CPX-POM Subcutaneous | CPX-O Oral |
| Body weight (kg) | 9.58 ± 0.49 | 9.91 ± 0.81 | 9.48 ± 0.64 |
| CPX dose (mg/kg)b | 3.10 ± 0.02 | 9.28 ± 0.09 | 9.39 ± 0.04 |
| test article dose (mg/kg)c | 7.30 ± 0.04 | 21.88 ± 0.14 | 12.14 ± 0.05 |
| UCPX (ng/ml) 0–24 h | 957 ± 508 | 2530 ± 958 | 1602 ± 750 |
| UCPX (μM) 0–24 h | 4.62 ± 2.45 | 12.2 ± 4.6 | 7.74 ± 3.62 |
| XeCPX (μg) 0–24 h | 208 ± 117 | 339 ± 206 | 299 ± 208 |
| FeCPX (%) | 0.70 ± 0.38 | 0.38 ± 0.24 | 0.32 ± 0.21 |
| Xe/dtCPX (μg/h) 0–8 h | 19.8 ± 15.2 | 23.0 ± 16.6 | 31.6 ± 26.2 |
| Xe/dtCPX (μg/h) 8–24 h | 3.10 ± 3.33 | 9.67 ± 9.49 | 2.90 ± 1.70 |
| Clr (ml/h/kg)d | 4.47 + 3.35 | ||
| FeCPX-G (%) | 49.2 ± 34.47 | 43.0 ± 19.7 | 37.0 ± 18.7 |
CPX, ciclopirox; CPX-G, ciclopirox glucuronide metabolite; CPX-O, ciclopirox olamine; CPX-POM, fosciclopirox; dXe/dtCPX, mass of CPX excreted per hour over × hours following drug administration; FeCPX, fraction of the administered dose excreted as CPX; FECPX-G, fraction of the administered dose excreted as CPX-G; UCPX, urine CPX concentration; XECPX, mass of CPX excreted in urine.
↵a N = 4 dogs who received all three treatments in a nonrandomized, complete crossover fashion.
↵b Ciclopirox free acid dose.
↵c CPX-POM disodium heptahydrate was formulated in 25 mM phosphate buffer pH 7 with 50 mM Captisol at a strength of 3.53 mg/ml (1.50 mg/ml ciclopirox free acid), CPX-O was formulated in 25 mM phosphate buffer pH 7 with 50 mM Captisol at a strength of 1.94 mg/ml (1.50 mg/ml ciclopirox free acid).
↵d Renal clearance calculated per kilogram body weight as Clr = Xecpx/AUC0∫∞.