1 | Rat | i.v. | CPX-O | 6.47 | 2.0 | 25 mM Phosphate Buffer, pH 7, 50 mM Captisol | 13.0 | 10.0 |
i.v. | CPX-POM | 8.72 | 2.0 | 25 mM Phosphate Buffer, pH 7, 50 mM Captisol | 17.5 | 7.4 |
2 | Dog | i.v. | CPX-O | 1.94 | 2.0 | 25 mM Phosphate Buffer, pH 7, 50 mM Captisol | 4.0 | 3.1 |
i.v. | CPX-POM | 2.61 | 2.0 | 25 mM Phosphate Buffer, pH 7, 50 mM Captisol | 5.4 | 2.3 |
3 | Rat | i.v. | CPX-POM | 23.53 | 2.1 | 25 mM Phosphate Buffer, pH 7, 50 mM Captisol | 47.0 | 20.0 |
s.c. | CPX-POM | 23.53 | 3.0 | 25 mM Phosphate Buffer, pH 7, 50 mM Captisol | 70.6 | 30.0 |
Oral | CPX-O | 29.39 | 1.3 | Orasweet SF, Water | 38.8 | 30.0 |
4 | Dog | i.v. | CPX-POM | 3.53 | 2.0 | 25 mM Phosphate Buffer, pH 7, 50 mM Captisol | 7.3 | 3.1 |
s.c. | CPX-POM | 3.53 | 6.0 | 25 mM Phosphate Buffer, pH 7, 50 mM Captisol | 21.8 | 9.3 |
Oral | CPX-O | 1.94 | 6.0 | Orasweet SF, Water | 12.2 | 9.3 |