TABLE 1

Echocardiographic and hemodynamic analysis of cardiac function in myeloid mPges-1 KO mice

Days after Coronary Ligation
0 (WT n = 13; KO n = 15)7 (WT n = 11; KO n = 13)28 (WT n = 10; KO n = 13)
Mac-mPges-1-WTMac-mPges-1-KOMac-mPges-1-WTMac-mPges-1-KOMac-mPges-1-WTMac-mPges-1-KO
Echocardiography
 Body weight (g)27.69 ± 0.5827.57 ± 0.6528.88 ± 0.8427.75 ± 0.8630.68 ± 0.84*28.53 ± 0.85
 LV mass (mg)85.40 ± 2.6182.02 ± 3020110.25 ± 6.00**96.97 ± 5.10109.19 ± 4.96**103.88 ± 6.69**
 LV mass/BW (mg/g)3.09 ± 0.082.97 ± 0.093.86 ± 0.28**3.47 ± 0.133.56 ± 0.143.61 ± 0.19**
 Heart rate (bpm)519.15 ± 14.64480.60 ± 16.52526.18 ± 10.57537.46 ± 14.25537.80 ± 10.05**543.62 ± 11.01**
 Cardiac output (ml/min)19.53 ± 0.8717.73 ± 1.1014.51 ± 0.75**16.65 ± 1.2117.00 ± 1.5120.16 ± 1.00
 Stroke volume (μl)37.50 ± 0.9436.63 ± 1.6927.75 ± 1.70**31.38 ± 2.6832.04 ± 3.2137.00 ± 1.69
 Ejection fraction (%)54.14 ± 1.8452.85 ± 1.0526.59 ± 2.84***35.84 ± 4.67***28.81 ± 3.37***37.14 ± 3.83**
 Fractional shortness (%)27.50 ± 1.5430.72 ± 1.1015.37 ± 2.15***20.18 ± 2.58***15.83 ± 2.45***20.15 ± 2.05***
 LV volume, end systole (μl)32.56 ± 2.4132.80 ± 1.7986.62 ± 12.48**71.04 ± 13.61*85.23 ± 9.74**80.02 ± 15.82**
 LV volume, end diastole (μl)70.06 ± 2.6269.43 ± 3.11114.37 ± 11.98**102.41 ± 12.0*117.27 ± 8.71**117.02 ± 15.87**
 LV internal diameter, end systole (mm)2.74 ± 0.122.52 ± 0.094.03 ± 0.26***3.43 ± 0.28*4.16 ± 0.3***3.65 ± 0.29**
 LV internal diameter, end diastole (mm)3.77 ± 0.103.63 ± 0.094.72 ± 0.19**4.23 ± 0.21*4.90 ± 0.22***4.50 ± 0.25**
Hemodynamics
 LV end systolic pressure (mm Hg)NDNDNDND91.90 ± 2.9587.36 ± 1.97
 LV end diastolic pressure (mm Hg)NDNDNDND7.48 ± 0.975.10 ± 0.75
 LV +dP/dt max (mm Hg/s)NDNDNDND7071.68 ± 563.296516.17 ± 308.48
 LV -dP/dt max (mm Hg/s)NDNDNDND6634.24 ± 403.966665.88 ± 241.52
 Tau (ms)NDNDNDND11.31 ± 0.6310.84 ± 0.40

  • BW, body weight; LV, left ventricular; ND, not determined.

  • ↵* P < 0.05;

  • ↵** P < 0.01;

  • ↵*** P < 0.001; 0 vs. 7 or 28 days post-MI.