TABLE 2

Echocardiographic analysis of cardiac function in global mPges-1 KO mice

Days after Coronary Ligation
0728
gWT (n = 4)gKO (n = 4)gWT (n = 8)gKO (n = 7)gWT (n = 14)gKO (n = 12)
Body weight (g)28.73 ± 1.3726.38 ± 1.2524.28 ± 3.2125.97 ± 3.5825.13 ± .0826.90 ± 2.29
LV mass (mg)92.78 ± 9.8982.71 ± 105890.88 ± 15.7991.19 ± 16.4286.35 ± 16.3284.05 ± 19.79
LV mass/BW (mg/g)3.24 ± 0.403.13 ± 0.303.76 ± 0.533.51 ± 0.453.49 ± 0.823.11 ± 0.63
Heart rate (bpm)454.00 ± 49.77401.75 ± 21.28471.63 ± 62.80481.43 ± 58.20456.36 ± 64.58460.17 ± 50.38
Cardiac output (ml/min)23.91 ± 4.6116.84 ± 0.8212.70 ± 5.4315.87 ± 4.9815.34 ± 3.4615.54 ± 2.33
Stroke volume (μl)53.69 ± 14.4641.97 ± 2.5628.06 ± 13.2533.38 ± 10.7034.01 ± 7.7834.26 ± 6.76
Ejection fraction (%)59.91 ± 5.8357.02 ± 2.4933.14 ± 19.5737.48 ± 23.4040.07 ± 16.6849.96 ± 19.42
Fractional shortness (%)28.40 ± 2.4828.60 ± 3.1619.07 ± 10.1420.18 ± 12.4922.63 ± 10.5228.27 ± 12.79
LV internal diameter, end systole (mm)2.92 ± 0.432.83 ± 1.893.82 ± 1.294.06 ± 1.823.45 ± 1.513.08 ± 1.72
LV internal diameter, end diastole (mm)4.07 ± 0.503.97 ± 0.114.63 ± 1.044.89 ± 1.524.32 ± 1.224.08 ± 1.40
  • BW, body weight; gKO, global mPges-1 KO; gWT, global mPges-1 WT; LV, left ventricular.