Summary of derived lung epithelial lining fluid and cell pellet GSK2292767A pharmacokinetic concentrations
| Measurement | N | n | Geometric Mean | 90% CI | Fold Change vs. Nemiralisiba |
|---|---|---|---|---|---|
| ng/ml | |||||
| Day 14 plasma Cmin | 9 | 9 | 0.06 | (0.03, 0.09) | Decrease (∼29-fold) |
| Pooled epithelial lining fluid drug concentration | 9 | 8 | 8.85 | (3.53, 22.22) | Decrease (∼6-fold) |
| Derived cell pellet concentration | 9 | 8 | 17,572 | (8278, 37,303) | Increase (∼48-fold) |
Cmin, trough concentration; N, total number of subjects; n, total number of subjects with sufficient samples with detectable levels of drug.
↵a Compared with previously reported data (Begg et al., 2019).