Drug | Therapeutic Dose | % Inhibition of AUCankle | Css averge | % Inhibition AHSS | ||
---|---|---|---|---|---|---|
AIA | CIA | AIA | CIA | |||
% | % | % | % | |||
Indomethacin | 25 mg three times daily | 40 | 52 | 1.12 µMa | 41 | 45 |
Methotrexate | 7.5 mg once weekly | 8 | 7 | 0.0133 µMb | ∼8 | ∼5 |
Etanercept | 50 mg once weekly | 5 | 16 | 1.77 µg/mlc | 14 | 29 |
Tofacitinib | 5 mg twice daily | 27 | 63 | 0.0580 µMd | 22 | 56 |
↵a From Helleberg (1981).
↵b Calculated using AUC/τ and data from Godfrey et al. (1998).
↵c Calculated using AUC/τ and data from Keystone et al. (2004).
↵d Determined by simulating a 5-mg twice daily dose using data from Cohen et al. (2010).
AUC/T = area under the concentration time profile/ dosing interval.