Effects of isoflurane on voltage-dependent activation and inactivation of neuronal Nav subtypes
Data are expressed as means ± S.D. Numbers in parentheses are the percentage change compared with the control.
| Subtype | V1/2act | V1/2inact | ||||
|---|---|---|---|---|---|---|
| CTL | ISO | Δ | CTL | ISO | Δ | |
| mV | ||||||
| Nav1.1 | −14.4 ± 3.4 | −15.4 ± 3.3 | −1.0 ± 1.1 (7) | −49.7 ± 3.9*,** | −54.6 ± 4.9*** | −4.9 ± 2.7 (10) |
| Nav1.2 | −15.8 ± 1.4 | −16.5 ± 0.8 | −0.6 ± 0.7 (4) | −57.5 ± 1.2* | −61.3 ± 1.4*** | −3.8 ± 1.7 (7) |
| Nav1.6 | −15.3 ± 2.0 | −16.3 ± 2.1 | −0.9 ± 0.5 (7) | −58.0 ± 3.8** | −64.2 ± 5.3*** | −6.2 ± 2.3 (11) |
CTL, control; ISO, isoflurane at 0.48 ± 0.03 mM (∼1.6 MAC).
↵* P < 0.05 (Nav1.1 vs. Nav1.2); **P < 0.05 (Nav1.1 vs. Nav1.6); ***P < 0.05 (CTL vs. ISO).