Pharmacodynamic parameters of methylphenidate in microdialysate after single intraperitoneal administration of methylphenidate to rats
Data represent mean ± S.D. (n = 4).
| Dose | Lmax_d | dAUEall | Tmax_d |
|---|---|---|---|
| mg/kg | (% of baseline) | (% of baseline × min) | min |
| 1 | 260 ± 132 | 7633 ± 8385 | 25.5 ± 22.7 |
| 3 | 346 ± 110 | 9418 ± 3216 | 19.5 ± 13.3 |
| 6 | 455 ± 72.5 | 20,324 ± 4414 | 16.5 ± 7.55 |
dAUEall, change in the area under the effect-time curve for the dopamine level from time zero to the last time; Lmax_d, maximum dopamine level; Tmax_d, time to reach the maximum dopamine level.