TABLE 3

Serum hormone concentrations and enzyme CMR values in all groups studied

For each sampling phase, measured values are reported as parameter estimates (mean values ± S.E.) and model results as estimated marginal means with 95% CIs (in parentheses).

Parameter measurednGroup 1 (n = 21)nGroup 2 (n = 15)nGroup 3 (n = 6)
EFPLFPLPEFPLFPLPEFPLFPLP
Estradiol (pg/ml)51.67 ± 4.70248.29 ± 20.10a121.67 ± 11.77b40.60 ± 5.6369.93 ± 7.95148.67 ± 25.96b29.67 ± 10.6649.63 ± 10.8349.67 ± 8.60
Progesterone (ng/ml)0.55 ± 0.070.69 ± 0.0912.18 ± 1.49b0.60 ± 0.090.81 ± 0.2012.70 ± 1.85b0.50 ± 0.101.13 ± 0.660.98 ± 0.26
LH (mIU/ml)5.30 ± 0.4017.25 ± 3.76a3.92 ± 0.455.00 ± 0.486.84 ± 0.636.28 ± 1.164.03 ± 0.516.38 ± 0.926.53 ± 1.04
FSH (mIU/ml)7.71 ± 0.457.64 ± 1.313.17 ± 0.26b7.40 ± 0.676.18 ± 0.613.78 ± 0.39b6.82 ± 1.445.58 ± 0.545.17 ± 0.98
CYP1A2
 All20c4.53
(3.93–5.13)3.49a
(3.09–3.88)a4.24
(3.80–4.68)154.31
(3.36–5.25)3.77d
(3.16–4.43)d4.35
(3.72–4.97)63.92
(3.03–4.80)4.12
(3.00–5.24)3.51
(2.81–4.22)
Nonsmokers14c3.02 ± 0.172.61 ± 0.173.08 ± 0.2183.52 ± 0.532.95 ± 0.323.14 ± 0.3433.31 ± 0.333.10 ± 0.553.18 ± 0.32
 CYP1A2*1F C/A72.86 ± 0.262.46 ± 0.142.84 ± 0.1554.05 ± 0.763.23 ± 0.483.33 ± 0.5333.31 ± 0.333.10 ± 0.553.18 ± 0.32
 A/A73.17 ± 0212.76 ± 0.323.31 ± 0.4032.63 ± 0.212.49 ± 0.122.83 ± 0.19
 C/C11.791.921.75
Smokers65.71 ± 0.834.32 ± 0.355.04 ± 0.5775.18 ± 0.594.90 ± 0.485.79 ± 0.4033.79 ± 0.924.11 ± 1.053.38 ± 0.62
 CYP1A2*1F C/A27.06 ± 2.224.47 ± 0.106.50 ± 0.9955.05 ± 0.845.19 ± 0.636.03 ± 0.5322.91 ± 0.493.06 ± 0.152.78 ± 0.23
 A/A45.04 ± 0.674.24 ± 0.554.31 ± 0.3525.49 ± 0.264.18 ± 0.105.20 ± 0.4515.546.204.59
CYP2A6
All210.60 ± 0.0270.70 ± 0.029a0.63 ± 0.028150.62 ± 0.0330.67 ± 0.028e0.56 ± 0.03060.57 ± 0.0470.65 ± 0.0340.68 ± 0.045
XO
All210.52 ± 0.0130.52 ± 0.0120.51 ± 0.010150.52 ± 0.0130.54 ± 0.0130.51 ± 0.01460.52 ± 0.0250.52 ± 0.0120.52 ± 0.028
NAT2
Slow110.074 ± 0.0070.090 ± 0.006a0.073 ± 0.006110.082 ± 0.0100.081 ± 0.0080.078 ± 0.00850.100 ± 0.0100.094 ± 0.0040.088 ± 0.010
Fast100.36 ± 0.0160.38 ± 0.0190.36 ± 0.01440.41 ± 0.0310.38 ± 0.0250.37 ± 0.02910.410.370.40
  • a LFP different from EFP (P < 0.01) and LP (P < 0.01).

  • b LP different from EFP and LFP (P < 0.01).

  • c C/C has been excluded from the model.

  • d LFP different from LP (P < 0.01) (but not from EFP, P = 0.056).

  • e LFP different from LP P = 0.027.