Drug | Intrinsic Hepatic Clearance (ml/min per kg) | Plasma Hepatic Clearance (ml/min per kg) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Observeda | Predicted | Observeda | Predicted | |||||||
Hepatocyte Total Uptake | Liver Microsomes Metabolism | Extended Clearance Model | Hepatocyte Substrate Depletion | Hepatocyte Total Uptake | Liver Microsomes Metabolism | Extended Clearance Model | Hepatocyte Substrate Depletion | |||
Bromfenac | 861.6 | 306.3 | 31.0 | 49.9 | 183.5 | 1.30 | 0.50 | 0.05 | 0.08 | 0.30 |
Entacapone | 1324.6 | 59.8 | 234.9 | 54.6 | 112.3 | 11.50 | 1.11 | 3.76 | 1.01 | 1.98 |
Fluorescein | 13.3 | 3.5 | 24.9 | 3.2 | — | 1.30 | 0.37 | 2.21 | 0.34 | — |
Nateglinide | 173.8 | 55.6 | 17.4 | 23.2 | 34.3 | 1.70 | 0.61 | 0.20 | 0.26 | 0.38 |
Diclofenac | 1220.2 | 391.9 | 160.5 | 255.2 | 213.5 | 3.47 | 1.34 | 0.58 | 0.91 | 0.77 |
Fenoprofen | 60.1 | 151.8 | 23.4 | 76.7 | 69.8 | 0.29 | 0.70 | 0.11 | 0.37 | 0.34 |
Gliclazide | 4.1 | 273.7 | — | — | 5.0 | 0.20 | 6.22 | — | — | — |
Ibuprofen | 71.7 | 107.3 | 26.7 | 50.8 | 71.2 | 0.81 | 1.17 | 0.32 | 0.59 | 0.81 |
Indomethacin | 102.2 | 236.9 | 10.6 | 35.4 | 28.4 | 1.10 | 2.31 | 0.12 | 0.40 | 0.32 |
Isoxicam | 2.0 | 228.6 | — | — | 5.7 | 0.07 | 4.70 | — | — | 0.20 |
Ketoprofen | 59.2 | 120.7 | 27.0 | 86.4 | 20.7 | 1.12 | 2.07 | 0.54 | 1.56 | 0.42 |
Meloxicam | 13.5 | 173.3 | 2.0 | 16.2 | 5.9 | 0.11 | 1.27 | 0.02 | 0.13 | 0.05 |
Pioglitazone | 127.3 | 1227.7 | 47.1 | 219.8 | 72.0 | 1.42 | 8.61 | 0.55 | 2.34 | 0.83 |
Piroxicam | 1.5 | 522.7 | — | — | 5.9 | 0.04 | 7.80 | — | — | 0.14 |
Pralidoxime | 8.6 | 5.3 | 11.5 | 4.8 | — | 3.65 | 2.42 | 4.60 | 2.20 | — |
Rosiglitazone | 203.9 | 1203.6 | 65.1 | 236.6 | 116.0 | 0.60 | 2.83 | 0.20 | 0.69 | 0.35 |
R-Warfarin | 3.9 | 107.1 | 0.2 | 8.6 | 1.9 | 0.05 | 1.25 | 0.00 | 0.11 | 0.02 |
Sulfamethoxazole | 1.0 | 11.4 | — | — | — | 0.31 | 3.16 | — | — | — |
S-Warfarin | 9.3 | 77.1 | 0.4 | 16.0 | 5.0 | 0.12 | 0.93 | 0.01 | 0.20 | 0.06 |
Tolbutamide | 7.9 | 35.2 | 1.9 | 17.5 | 6.1 | 0.21 | 0.88 | 0.05 | 0.45 | 0.16 |
Tolcapone | 1010.4 | 674.6 | 77.9 | 239.3 | 131.5 | 1.49 | 1.04 | 0.13 | 0.39 | 0.22 |
Clinafloxacin | 1.8 | 38.5 | — | — | — | 1.50 | 8.71 | — | — | — |
Naproxen | 3.9 | 94.1 | 4.3 | 4.2 | 24.6 | 0.10 | 2.16 | 0.11 | 0.11 | 0.62 |
Thalidomide | 6.2 | 0.5 | 3.3 | 0.4 | 21.9 | 2.19 | 0.18 | 1.25 | 0.16 | 5.95 |
Tiagabine | 11.4 | 281.4 | — | — | 18.2 | 1.57 | 9.09 | — | — | 2.32 |
↵a Observed plasma hepatic clearance was obtained from Davis et al. (2000), Delrat et al. (2002), Scordo et al. (2002), Obach et al. (2008), Varma et al. (2009), El-Kattan et al. (2016). Observed intrinsic hepatic clearance was calculated from plasma hepatic clearance using eq. 7.