Species | Oral Cmax at 10 mg/kg | Oral Tmax at 10 mg/kg | Oral AUC 0–∞ | CLp | Vdss | t1/2 | Oral F |
---|---|---|---|---|---|---|---|
nM | h | nM/h per milliliter | ml/min per kilogram | l/kg | h | % | |
Mouse | 11,884 | 1.3 | 58,440 | 4.5 | 0.7 | 1.9 | 51 |
Rat | 20,844 | 0.4 | 133,162 | 4.5 | 1.3 | 4.1 | ∼100 |
Dog | 19,486 | 2.3 | 335,615 | 1.9 | 0.9 | 7 | ∼100 |
AUC, area under the curve; CLp, plasma clearance; Oral F, oral bioavailibility; t1/2, half-life; Tmax, time to maximal concentration; Vdss, volume of distribution.