TABLE 1

Top human SNPs associated with acetaminophen-induced hepatotoxicity [Court et al. (2014), n = 78 intentional, 79 unintentional, 103 control]

SNPGeneNameAllelesaMAFCategoryOdds RatiobP Value
rs8330UGT1AUDP glucuronosyltransferase family 1 member A complex locusC/G0.263′UTRc0.53 (0.3–0.94)0.027
rs776746CYP3A5Cytochrome P450 family 3 subfamily A member 5G/A0.38Intron2.3 (1.1–4.9)0.034
rs1467558CD44CD44 moleculeC/T0.06Missense4.0 (1.0–17.2)0.045
  • a Major allele/minor allele.

  • b OR (95% confidence interval).

  • c Untranslated region.