TABLE 2

Properties related to 27 surveyed therapeutic antibodies

Antibody	Average K_D	Target	Target Tissue	ISF Turnover	Reference^{^a}
	nM			h⁻¹
Bevacizumab	1.10	VEGF	Tumor	0.0001	Carter (2006)
Romosozumab	0.01	Sclerostin	Bone	0.003	Chouinard et al. (2016)
Eculizumab	0.12	C5	Muscle	0.007	Rother et al. (2007)
Belimumab	0.20	BAFF	Whole body	0.0077	Zhou and Theil (2015)
Ranibizumab	0.046	VEGF	Whole body	0.0077	Platania et al. (2015)
Adalimumab	0.55	TNF-α	Colon	0.04	Song et al. (2008)
Bezlotoxumab	0.75	Clostridium difficile	Colon	0.04	Hernandez et al. (2015)
Infliximab	1.92	TNF-α	Colon	0.04	Kim et al. (2007)
Brodalumab	0.239	IL-17RA	Skin	0.05	Greig (2016)
Ixekizumab	0.0018	IL-17A	Skin	0.05	Liu et al. (2016)
Secukinumab	0.166	IL-17A	Skin	0.05	Beerli et al. (2014)
Ustekinumab	0.10	IL-12, IL-23	Skin	0.05	De Luca and Trifonova (2017)
Adalimumab	0.55	TNF-α	Joint synovium	0.15	Song et al. (2008)
Canakinumab	0.031	IL-1β	Joint synovium	0.15	Rondeau et al. (2015)
Certolizumab Pegol	0.09	TNF-α	Joint synovium	0.15	Patel and Moreland (2010)
Etanercept	5.10	TNF-α	Joint synovium	0.15	Kim et al. (2007)
Golimumab	0.018	TNF-α	Joint synovium	0.15	Shealy et al. (2010)
Infliximab	1.92	TNF-α	Joint synovium	0.15	Kim et al. (2007)
Mavrilimumab	0.103	GM-CSF	Joint synovium	0.15	Wang et al. (2018)
Mepolizumab	0.0042	IL-5	Lung	1.21	Hart et al. (2001)
Obiltoxaximab	0.33	Bacillus anthracis	Lung	1.21	Nagy et al. (2017)
Omalizumab	0.17	IgE	Lung	1.21	Carter (2006)
Raxibacumab	2.78	Anthrax toxin	Lung	1.21	Mazumdar (2009)
Reslizumab	0.02	IL-5	Lung	1.21	Amini-Vaughan et al. (2012)
Canakinumab	0.031	IL-1β	Kidney	1.46	Rondeau et al. (2015)
Siltuximab	0.034	IL-6	Lymph node	7.91	Deisseroth et al. (2015)
Abciximab	5.00	GPIIb/IIIa	Plasma	58.19	Carter (2006)
Alirocumab	0.58	PCSK9	Plasma	58.19	Poirier and Mayer (2013)
Belimumab	0.2	BAFF	Plasma	58.19	Zhou and Theil (2015)
Evolocumab	0.008	PCSK9	Plasma	58.19	Gibbs et al. (2017)
Idarucizumab	0.002	Dabigatran	Plasma	58.19	Eikelboom et al. (2015)

BAFF, B-cell activating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; VEGF, vascular endothelial growth factor.
↵^a The source of the average K_D values for each antibody.