TABLE 1

Inhibitory effects of test compounds on SW-620 human colon cancer cell viability

Data are the mean ± S.E.M. of at least three independent experiments, each performed in triplicate. Data (>100); not significant activity found at 150 µM concentration, after 48-hour treatment.

CompoundIC50 (µM)aGI50 (µM)bTGI (µM)cLC50 (µM)d
13>100>100>100>100
1429.5 ± 10.1810.5 ± 1.5556.25 ± 7.4675.5 ± 5.42
152 ± 01.58 ± 0.0810.33 ± 1.4519.33 ± 2.85
160.83 ± 0.0830.57 ± 0.06714.47 ± 12.7775 ± 25
172.67 ± 0.671.83 ± 0.083>100>100
2043.33 ± 4.4124.33 ± 8.29>100>100
245.17 ± 1.172.33 ± 0.3336.67 ± 4.4163.33 ± 8.33
SF-6>100>100>100>100
4,4′-Di-O-MEA5.97 ± 1.091.58 ± 0.18143.3 ± 23.66>100
  • 4,4′-Di-O-MEA, 4,4′-di-O-methylellagic acid.

  • a Effective concentration, or compound concentration required for 50% inhibition of cell proliferation, after 48-hour treatment.

  • b Compound concentration required for 50% cell growth inhibition, after 48-hour treatment.

  • c Compound concentration required for total cell growth inhibition, after 48-hour treatment.

  • d Compound concentration required for 50% cell death, after 48-hour treatment.