TABLE 1

Inhibitory effects of test compounds on SW-620 human colon cancer cell viability

Data are the mean ± S.E.M. of at least three independent experiments, each performed in triplicate. Data (>100); not significant activity found at 150 µM concentration, after 48-hour treatment.

Compound	IC₅₀ (µM)^{^a}	GI₅₀ (µM)^{^b}	TGI (µM)^{^c}	LC₅₀ (µM)^{^d}
13	>100	>100	>100	>100
14	29.5 ± 10.18	10.5 ± 1.55	56.25 ± 7.46	75.5 ± 5.42
15	2 ± 0	1.58 ± 0.08	10.33 ± 1.45	19.33 ± 2.85
16	0.83 ± 0.083	0.57 ± 0.067	14.47 ± 12.77	75 ± 25
17	2.67 ± 0.67	1.83 ± 0.083	>100	>100
20	43.33 ± 4.41	24.33 ± 8.29	>100	>100
24	5.17 ± 1.17	2.33 ± 0.33	36.67 ± 4.41	63.33 ± 8.33
SF-6	>100	>100	>100	>100
4,4′-Di-O-MEA	5.97 ± 1.09	1.58 ± 0.18	143.3 ± 23.66	>100

4,4′-Di-O-MEA, 4,4′-di-O-methylellagic acid.
↵^a Effective concentration, or compound concentration required for 50% inhibition of cell proliferation, after 48-hour treatment.
↵^b Compound concentration required for 50% cell growth inhibition, after 48-hour treatment.
↵^c Compound concentration required for total cell growth inhibition, after 48-hour treatment.
↵^d Compound concentration required for 50% cell death, after 48-hour treatment.