TABLE 2

Inhibition of monoamine uptake in vitro by TAS-303 and duloxetine

IC50 values for monoamine uptake were determined from three independent experiments using seven drug concentrations. Results are shown as the mean ± S.E.M.

CompoundMonoamine Uptake IC50Selectivity
NETSERTDATSERT/NETDAT/NET
nM
TAS-30338.9 ± 2.83080 ± 24028,300 ± 200079726
Duloxetine4.03 ± 0.283.52 ± 0.56149 ± 90.8737