TABLE 1

Whole-bladder responses from saline-, MMC-, saline + ibuprofen–, and MMC + ibuprofen–treated mice: filling volume at 40 mmHg pressure, pressure response to ATP (10 mM) and KCl (60 mM), pEC50 and maximal responses (millimeter of mercury) to carbachol and pIC50, and maximal responses to isoprenaline

Data presented are mean ± S.E.M. (n = 6) analyzed using one-way ANOVA with Bonferroni multiple comparisons test.

SalineMMCSaline + IBUMMC + IBU
Filling volume at 40 mmHg (μl)481 ± 74.6513 ± 68.1487 ± 40.6513 ± 28.1
Pressure Response
 ATP (1 mM) (mmHg)1.11 ± 0.292.39 ± 0.672.14 ± 0.671.87 ± 0.37
 KCl (60 mM) (mmHg)16.8 ± 4.7910.04 ± 3.5513.58 ± 1.5213.32 ± 4.03
Carbachol
 pEC505.85 ± 0.225.85 ± 0.276.05 ± 0.126.03 ± 0.16
 Maximal response (mmHg)28.44 ± 6.3623.69 ± 6.0929.45 ± 3.3228.82 ± 4.56
Isoprenaline
 pIC507.03 ± 0.337.46 ± 0.567.29 ± 0.227.05 ± 0.35
 Maximal response (mmHg)2.56 ± 0.391.92 ± 0.742.65 ± 0.352.26 ± 0.38